Edward Mellanby M.D., F.R.C.P., F.R.S.
	Vitamin A 
    Infection & nutrition  
[Vitamin A was named the “anti-infective vitamin” in 1928 by Edward Mellanby (1884-1955) and Harry N. Green, both doctors at the University of Sheffield.]
See: Sandler, M.D., Benjamin P.
[2006] Cod Liver Oil: The 
Number One Superfood by Krispin Sullivan, CN  The most fascinating part 
of this little book is the chapter describing the experiments done in England by 
a Mrs. May Mellanby. Her husband, Dr. E. Mellanby, was the author of over 400 
studies and the first to control rickets with diet. Cod liver oil had been used 
for centuries as a remedy but the specific application to rickets was first 
demonstrated by Dr. Mellanby. (Control of rickets using UV-B light was 
demonstrated almost simultaneously by investigators at Columbia and Johns 
Hopkins University in 1921.) In his research into rickets in dogs, he discovered 
the mineral-blocking effect of phytic acid in grains and legumes. Dr. Mellanby 
demonstrated that diets containing high levels of cereals, especially oatmeal, 
and lacking vitamin D, are the most effective producers of rickets. If vitamin D 
is inadequate there is poor tooth development, but Mrs. Mellanby then went on to 
prove that no matter how much cereal is fed, if vitamin D is adequate tooth 
formation is normal. Mrs. Mellanby believed that as cereals increase in the 
diet, vitamin D must also be increased to offset their anticalcifying 
effects—think of the implications of this research on today's baby-feeding 
habits, where infants are given cereals as their first food but denied egg yolks 
until they are one year old! 
    Mrs. Mellanby also determined that vitamin D must be present 
from conception in order for proper tooth formation to occur. If vitamin D is 
absent during the early gestational period, the enamel cannot form properly, and 
it cannot be repaired by giving vitamin D later. 
    In her initial studies Mrs. Mellanby used dogs as the source 
of data but she later examined more than one thousand "baby" teeth from 
children. She divided these teeth into four categories—normal, hypoplastic 
(slightly underdeveloped), moderately underdeveloped and grossly underdeveloped. 
Only 149, or about 14 percent, of the total 1,036 were sound. About one-quarter 
were slightly underdeveloped, but nearly two-thirds were moderately or grossly 
underdeveloped. 
    It is more difficult to examine teeth in place, but of 266 
adult teeth examined by Mrs. Mellanby, not one was sound. The teeth were 
extracted only for purposes of straightening the teeth, which means that they 
were erupting in a jaw that was underdeveloped. Thus, children with narrow faces 
most likely have underdeveloped teeth. Tooth structure and later decay are 
directly related. Prevention of cavities must start in the womb. 
Book
[Chapter 4: 
CHAPTER 4 
NUTRITION AND INFECTION] NUTRITION AND DISEASE. THE INTERACTION OF CLINICAL AND EXPERIMENTAL WORK by Edward Mellanby M.D., F.R.C.P., F.R.S.