Vasculomyelinopathy & vaccination
Vaccine disease
Reik L Jr.Disseminated vasculomyelinopathy: an immune
complex disease.Ann Neurol. 1980 Apr;7(4):291-6.PMID:
6445707 [PubMed - indexed for MEDLINE]
The numerous nervous system abnormalities which follow antecedent infections and
immunization appear to share a common pathogenesis involving the immune system.
Pathologically, a small vessel vasculopathy involving arterioles and capillaries as well
as venules in both gray and white matter is the earliest and most consistent change.
Perivascular demyelination appears to develop subsequently. Delayed hypersensitivity to
myelin basic protein may not adequately account for these changes. Humoral immunity may be
involved instead. I postulate that antigen-antibody complexes, formed following the
introduction of foreign antigen by infection or inoculation, cause vascular injury with
secondary damage to myelin. There is considerable evidence that circulating immune
complexes are present in some postinfectious nervous system disorders, as are associated
systemic features which suggest immune complex disease. Similar clinical and pathological
nervous system changes occur in a variety of disorders in which circulating immune
complexes are thought to cause vascular injury.
[1980] Disseminated Vasculomyelinopathy: An Immune Complex Disease---Louis Reik, Jr, MD
Poser
CM, Roman G, Emery ES 3rd. Recurrent disseminated
vasculomyelinopathy.Arch Neurol. 1978 Mar;35(3):166-70.
PMID: 629662 [PubMed - indexed for MEDLINE]
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